Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/296898733?client_source=feed&format=rss
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Friday, April 5, 2013
Thursday, April 4, 2013
Banks say do not plan big increase in corporate lending in second quarter - BoE
LONDON (Reuters) - British banks do not expect to be more willing to lend to companies in the second quarter despite a probable increase in demand, a Bank of England survey showed on Wednesday.
The central bank's Credit Conditions Survey showed availability of credit for companies increased in the first three months of 2013 but was confined to large firms and the pace of growth was slower than in the fourth quarter.
Banks reported that small companies showed a big fall in demand for credit as the firms worried about a fragile economic outlook and that banks had a low tolerance for risky loans, the BoE survey said.
Banks polled for the BoE's quarterly Credit Conditions Survey said they would increase the availability of mortgages in the second quarter of 2013 after a rise in the January-March period.
Demand for mortgages increased in the first quarter, albeit at a slower pace than in the previous three months, and was expected to increase significantly in the second quarter.
The BoE's flagship Funding for Lending Scheme was launched last year as the latest attempt to get more credit flowing into the economy. So far, the scheme has had more of an impact on lending for mortgages than on loans for companies.
Banks said the FLS helped them reduce borrowing costs for households and companies and they expected a further tightening of loan spreads in the next three months, the BoE survey found.
(Reporting by David Milliken and William Schomberg)
Source: http://news.yahoo.com/banks-not-plan-big-increase-corporate-lending-second-083315702--business.html
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Walking can lower risk of heart-related conditions as much as running
Apr. 4, 2013 ? Walking briskly can lower your risk of high blood pressure, high cholesterol and diabetes as much as running can, according to surprising findings reported in the American Heart Association journal Arteriosclerosis, Thrombosis and Vascular Biology.
Researchers analyzed 33,060 runners in the National Runners' Health Study and 15,045 walkers in the National Walkers' Health Study. They found that the same energy used for moderate intensity walking and vigorous intensity running resulted in similar reductions in risk for high blood pressure, high cholesterol, diabetes, and possibly coronary heart disease over the study's six years.
"Walking and running provide an ideal test of the health benefits of moderate-intensity walking and vigorous-intensity running because they involve the same muscle groups and the same activities performed at different intensities," said Paul T. Williams, Ph.D., the study's principal author and staff scientist at Lawrence Berkeley National Laboratory, Life Science Division in Berkeley, Calif.
Unlike previous studies, the researchers assessed walking and running expenditure by distance, not by time. Participants provided activity data by responding to questionnaires.
"The more the runners ran and the walkers walked, the better off they were in health benefits. If the amount of energy expended was the same between the two groups, then the health benefits were comparable," Williams said.
Comparing energy expenditure to self-reported, physician-diagnosed incident hypertension, hypercholesterolemia, diabetes and coronary heart disease, researchers found:
- Running significantly reduced risk for first-time hypertension 4.2 percent and walking reduced risk 7.2 percent.
- Running reduced first-time high cholesterol 4.3 percent and walking 7 percent.
- Running reduced first-time diabetes 12.1 percent compared to 12.3 percent for walking.
- Running reduced coronary heart disease 4.5 percent compared to 9.3 percent for walking.
"Walking may be a more sustainable activity for some people when compared to running, however, those who choose running end up exercising twice as much as those that choose walking. This is probably because they can do twice as much in an hour," Williams said.
Study participants were 18 to 80 years old, clustered in their 40s and 50s. Men represented 21 percent of the walkers and 51.4 percent of the runners.
"People are always looking for an excuse not to exercise, but now they have a straightforward choice to run or to walk and invest in their future health," Williams said.
Co-author is Paul D. Thompson, M.D.
The National Heart, Lung, and Blood Institute funded the study.
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The above story is reprinted from materials provided by American Heart Association.
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Journal Reference:
- Paul T. Williams and Paul D. Thompson. Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction. Arteriosclerosis, Thrombosis and Vascular Biology, April 4 2013 DOI: 10.1161/ATVBAHA.112.300878
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/JV5Aqd_QSlQ/130404170225.htm
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Obama raises California money for Democrats
President Barack Obama stands with a view of the Golden Gate bridge before getting on Marine One in San Francisco, Thursday, April 4, 2013. Obama will be attending Democratic fundraisers while in California. (AP Photo/Susan Walsh)
President Barack Obama stands with a view of the Golden Gate bridge before getting on Marine One in San Francisco, Thursday, April 4, 2013. Obama will be attending Democratic fundraisers while in California. (AP Photo/Susan Walsh)
Protestors gather and march from San Francisco's Alta Plaza Park to demonstrate against Kestone Pipeline while President Barack Obama is in the city Wednesday March 3, 2013. (AP Photo/The San Francisco Examiner, Anna Latino )
President Barack Obama waves from the top of the steps of Air Force One at San Francisco International Airport in San Francisco, Wednesday, April 3, 2013. Obama will be attending Democratic fundraisers while in California. (AP Photo/Susan Walsh)
SAN FRANCISCO (AP) ? Making a down payment on his vow to go all in for Democrats in 2014, President Barack Obama is courting well-heeled donors in California on a two-day fundraising jaunt that requires him to walk a fine line: Berate Republicans too much, and Obama could put fragile prospects for achieving his second-term goals in jeopardy.
Obama's California swing kicks off a concerted effort to help his party win back the House and keep its Senate majority next year. It's a mission that, if successful, would improve his playing field and help him secure his legacy during his final two years in office, a lame-duck period in which a president's influence quickly ebbs.
At an intimate gathering of high-dollar donors in Silicon Valley on Thursday, Obama said that political gridlock continues to stymie progress, but that Americans are not as divided as Washington makes it seem.
"Our policies, the ones that we presented, traditionally would be considered pretty bipartisan," Obama said. "There's nothing particularly Democratic about road-building or basic science or environmental protection."
Obama's appearance at the $32,400-a-person brunch benefiting the Democratic National Committee was one of four stops on a fundraising tour that started on Wednesday, when Obama raised $3.25 million for the House Democrats' campaign committee.
The blitz continued Thursday with the brunch in the ritzy town of Atherton, near Stanford University. Obama was to finish the fundraising swing Thursday afternoon at a luncheon at the home of philanthropists Marcia and John Goldman, where donors to the national Democratic Party can pay $1,000 to attend or $5,000 for the chance to take a photo with the president.
The short-term pitfalls of the campaign effort are clear. Obama has spent much of the past month pursuing warmer relations with Republicans in Congress whose votes he needs to enact his agenda. Republicans on the receiving end of Obama's ongoing "charm offensive" ? the president will dine with Senate Republicans next week for a second time ? say his partisan tone when he leaves Washington makes them question his sincerity when he says he's willing to meet Republicans halfway.
"He's doing a pretty lousy job of it," Reince Priebus, the chairman of the Republican Party, said in an interview. "If he was someone who was as conciliatory as he proclaims to be, you would think he would have a few decent relationships with Republicans, but he doesn't. Instead, he spends most of his time campaigning."
White House officials are mindful of the balancing act Obama must carry out to avoid undermining relations with Republican lawmakers when he hits the campaign trail for Democrats.
"The president's appeal to his supporters won't interfere with his continued efforts to work with Republicans to move that agenda through the Congress," White House spokesman Josh Earnest said.
Almost immediately after winning re-election in November, Obama made clear he would put his full weight behind efforts to elect Democrats in the 2014 midterms, upping his commitment from previous years. During Obama's first term, some Democrats complained he didn't do enough to help ? especially in 2010, when Democrats lost control of the House.
This time, Democratic officials say, Obama will headline at least 20 fundraisers: six for House Democrats, six for Senate Democrats and two joint House-Senate events, plus another half-dozen or so for the Democratic National Committee, which is still retiring the debt it racked up last year helping Obama win a second term.
Jim Messina, Obama's 2012 campaign manager, personally delivered the commitment for the House fundraisers in February to Rep. Steve Israel, who chairs the Democratic Congressional Campaign Committee, said one official, who spoke on condition of anonymity because the conversations were private.
Israel and House Minority Leader Pelosi, D-Calif., joined Obama for the fundraisers on Wednesday, where Obama told donors he'd be able to "get a whole lot more done" with Pelosi in charge of a Democratic-controlled House.
But accolades to his Democratic colleagues aside, Obama refrained from lobbing partisan barbs at Republicans in his remarks on Wednesday, which were closed to cameras but open to a small group of reporters. Instead, Obama implored donors to get behind candidates who see eye to eye with him on climate change, research spending, public works projects and early childhood education.
"I'm going to need some help," Obama said.
Still, he added: "My intention here is to try to get as much done with the Republican Party over the next two years as I can, because we can't have perpetual campaigns."
The rhetoric was not so inclusive from Israel, the House Democrats' campaign chief. After Obama spoke and reporters were ushered out on Wednesday, Israel described Republicans as full of "obstruction, chaos, inflexibility and intolerance," according to a campaign committee official who relayed some of his remarks.
Democrats need to pick up 17 seats next year to regain control of the House ? no small feat, considering that a president's party tends to lose House seats in the midterms during a second term. In the Senate, Democrats are defending a daunting 21 seats, including seven in largely rural states where Republican Mitt Romney defeated Obama last year. Republicans must flip just six seats to claim the majority.
Vice President Joe Biden, too, is expected to play a major role in helping Democrats defeat their GOP challengers. Israel told supporters at an annual conference last month that Biden has been busy making calls to potential candidates to recruit them to run.
Republican skepticism that Obama is serious about wanting to mend fences with GOP lawmakers was bolstered earlier this year when the president, fresh off his high-intensity re-election, blasted Republicans in campaign-style events for blocking his preferred approach to averting the sequester, the automatic, across-the-board spending cuts that kicked in on March 1. Republicans say it felt like the 2012 campaign never ended, making it harder to take Obama's recent outreach at face value.
"I'll admit, it's very difficult to do both. That's why he shouldn't do both," said Rep. Tim Griffin, R-Ark., the vice chairman of the National Republican Congressional Committee. "He needs to put the campaign rhetoric aside, roll up his sleeves and demonstrate a willingness to work with House Republicans on tax reform, entitlement reform and the problems driving our debt."
"I just don't get the sense that his little outreach was anything more than a charade," Griffin added.
Sara Taylor Fagen, the former political director for President George W. Bush, said there's no reason a president can't carry out his duties to his party and his country simultaneously. But she said an administration gets in trouble when the president doesn't strike the right balance or adopts too harsh a tone.
"You have an obligation to help your party win seats. You want to help them win," Fagen said. "You don't necessarily want to draw a lot of attention to the fact you're spending your evening talking about building the party."
___
Lederman reported from Washington.
___
Follow Josh Lederman on Twitter: http://twitter.com/joshledermanAP
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Crucial step in human DNA replication observed for the first time
Tuesday, April 2, 2013
For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human DNA replication is performed." The results of the research will be published in the journal eLife on 2 April 2013.
Part of the DNA replication process -- in humans and in other life forms -- involves loading of molecular structures called sliding clamps onto DNA. This crucial step in DNA replication had remained somewhat mysterious and had not been well studied in human DNA replication. Mark Hedglin, a post-doctoral researcher in Penn State's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band. The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material. "Without a sliding clamp, polymerases can copy very few bases -- the molecular 'letters' that make up the code of DNA -- at a time. But the clamp helps the polymerase to stay in place, allowing it to copy thousands of bases before being removed from the strand of DNA," Hedglin said.
Hedglin explained that, due to the closed circular structure of sliding clamps, another necessary step in DNA replication is the presence of a "clamp loader," which acts to latch and unlatch the sliding clamps at key stages during the process. "The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin. "We know that polymerases and clamp loaders can't bind the sliding clamp at the same time, so the hypothesis was that clamp loaders latched sliding clamps onto DNA, then left for some time during DNA replication, returning only to unlatch the clamps after the polymerase left so they could be recycled for further use."
To test this hypothesis, the team of researchers used a method called F?rster resonance energy transfer (FRET), a technique of attaching fluorescent "tags" to human proteins and sections of DNA in order to monitor the interactions between them. "With these tags in place, we then observed the formation of holoenzymes -- the active form of the polymerase involved in DNA replication, which consists of the polymerase itself along with any accessory factors that optimize its activity," Hedglin said. "We found that whenever a sliding clamp is loaded onto a DNA template in the absence of polymerase, the clamp loader quickly removed the clamp so that free clamps did not build up on the DNA. However, whenever a polymerase was present, it captured the sliding clamp and the clamp loader then dissociated from the DNA strand."
The team members also found that, during the moments when both the clamp loader and the clamp were bound to the DNA, they were not intimately engaged with each other. Rather, the clamp loader released the closed clamp onto the DNA, allowing an opportunity for the polymerase to capture the clamp, completing the assembly of the holoenzyme. Subsequently, the clamp loader dissociated from DNA. "Our research demonstrates that the DNA polymerase holoenzyme in humans consists of only a clamp and a DNA polymerase. The clamp loader is not part of it. It disengages from the DNA after the polymerase binds the clamp," Hedglin added.
Benkovic noted that this mechanism provides a means for the cell to recycle scarce clamps when they are not in use for productive replication.
###
Penn State: http://live.psu.edu
Thanks to Penn State for this article.
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Source: http://www.labspaces.net/127551/Crucial_step_in_human_DNA_replication_observed_for_the_first_time
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Copyright Trolls Offer No Defense to Frustrated Federal Judge ...
A federal judge in Los Angeles today showed little restraint in expressing his frustration with the "attorney misconduct" he's identified by the prominent copyright trolls behind Prenda Law. All of the named representatives of the firm appeared at today's session, after Judge Otis D. Wright II complained about their failure to do so at a similarly dramatic March 11 hearing.
Until today, nobody was sure of who would actually appear. Prenda lawyers Paul Hansmeier, Paul Duffy, and John Steele were present, as well as Peter Hansmeier (Paul's brother and the technical expert in Prenda cases), Mark Lutz (a non-lawyer who worked with Steele Hansmeier and who is the CEO of various Prenda clients), former counsel Brett Gibbs, and Prenda paralegal Angela Van Den Hemel ? a full house except for ?Alan Cooper of AF Holdings, LLC.?? (Alan Cooper of Isle, Minnesota, who testified at the March 11 hearing, made it clear that he had no connection to AF Holdings.)? Judge Wright said he was "pleasantly surprised" that everybody was able to make it to the hearing, as otherwise he would be forced to "draw reasonable inferences" from the facts presented to him.
But after that short introduction, Judge Wright discovered he would be forced to draw those inferences anyway. First lawyers for John Steele and for Paul Hansmeier, and then Heather Rosing, the lawyer for Duffy, Prenda Law and Van Den Hemel, claimed that their clients would be exercising their Fifth Amendment rights not to testify. "If you say his testimony will incriminate him, I'll take you at your word," Judge Wright responded. The Fifth Amendment provides the right for people not to testify against themselves; it prevents an adverse inference in criminal matters, but courts may allow adverse inferences in civil actions when someone refuses to testify in response to evidence offered against them. Judge Wright, clearly frustrated, said he was simply seeking to uncover the facts of the case: "Let's cut to the chase: I want to know if some of my conjecture is accurate." Given that Paul Hansmeier, Duffy, Steele, and Van Den Hemel would not testify, he was left with little clarification.
(Peter Hansmeier and Mark Lutz were present but not represented by counsel. Judge Wright didn't ask them directly whether they would testify or take the Fifth.)
Judge Wright asked why Prenda Law concealed its attorneys' financial interest in the underlying cases. Rosing,?the attorney for Duffy, Prenda Law and Van Den Hemel, responsed that there was "no evidence that they have an interest." Judge Wright was incredulous: "Have you read Paul Hansmeier's deposition?" Rosing asked for the chance to offer a legal argument, but Judge Wright wasn't going to allow it at the hearing. She then offered to submit the argument as a brief, which Wright agreed to before adjourning the hearing after about 12 minutes. "We're done."
We're waiting to hear more from Judge Wright. Although he said in the hearing that "The court's interest has shifted from protecting intellectual property interests to attorney misconduct," there are still some unresolved issues. For one, EFF represents two anonymous bloggers that Duffy and Prenda have sued for defamation after their reporting on Prenda's cases. Ken White at Popehat has a detailed report.
Source: https://www.eff.org/deeplinks/2013/04/copyright-trolls-offer-no-defense-frustrated-federal-judge
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